
SuperF4 is a light weight, open source Windows utility that kills running apps dead. Just hit Ctrl+Alt+F4 and whatever program is in the foreground will terminate instantly. You won't get a warning or a prompt to save your work. It'll just close.
Sure, you could do something similar by firing up the Windows task manager, locating the running process and terminating it. But SuperF4 accomplishes this much, much faster. You can also press the Windows key + F4 to turn your mouse cursor into a skull and crossbones. The next program you click on will be terminated.